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KMID : 0361020000430111073
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Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 11 p.1073 ~ p.1077
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Histopathology of Amniotic Fluid cellular Contents in the Middle Ear of Neonate
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Jang Chul-Ho
Clarinda Northrop
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Abstract
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Background and Objective: Amniotic fluid appears quite early during pregnancy and evolves into a complex liquor. The fluid exists in a state of dynamic circulation and is composed of a variety of biochemical elements. Amniotic fluid cellular content (AFCC) originates from the fetal epidermis(flat, keratinized, non-nucleated cells and lanugo hair), amnion and others. The purpose of this study is to investigate the possibility of development of the granulation, otitis media and cholesteatoma after innoculation of AFCC in newborn middle ear.
Materials and Method: Fifty two temporal ones aged 1 to 80days were examined by light microscopy.
Results: Several types of histopathological features were observed. The most common finding was granulation tissue(38 bones). As a general pattern, scattered particles of AFCC, including hair, were being phagocytized(35 bones). Hyperplastic mucosal epithelium was demonstrated (33 bones). Various degree of purulent otitis media were detectable in 30 bones. Red blood cells were common finding. The least involved was the mere presence of AFCC with no mucosal reaction.
Conclusion: These results suggest some theoretical linical implications of granulation and purulent otitis media by adhesion of AFCC in the middle ear.
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KEYWORD
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Amniotic fluid, Newborn temporal bone
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